Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Avoid getting sirolimus liquid on your skin or around your nose. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water. Appropriate studies have not been performed on the relationship of age to the effects of danazol in the pediatric population. Safety and efficacy have not been established. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.
Wentz AC "Adverse effects of danazol in pregnancy. Danocrine is indicated for the treatment of endometriosis amenable to hormonal management. Webb AM, Russell J, Elstein M "Comparison of Yuzpe regimen, danazol, and mifepristone RU486 in oral postcoital contraception. Your doctor may adjust your dose as needed and tolerated. Tell your doctor or dentist that you take danazol before you receive any medical or dental care, emergency care, or surgery.
The information contained in the Truven Health Micromedex products as delivered by Drugs. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danocrine. A nonhormonal method of contraception is recommended when Danocrine is administered at this dose, since ovulation may not be suppressed. In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danocrine is usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy.
What should I discuss with my healthcare provider before taking danazol Danocrine? These hormones usually make the conditions worse. Avoid exposure to sunlight or tanning beds. Sirolimus may increase your risk of skin cancer. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Do not keep outdated medicine or medicine no longer needed. Danazol Capsules USP are indicated for the treatment of endometriosis amenable to hormonal management. If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine. Although appropriate studies on the relationship of age to the effects of danazol have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. The total daily dosage of Danazol capsules for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules. A non-hormonal method of contraception is recommended when Danazol capsules are administered at this dose, since ovulation may not be suppressed.
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. What happens if I overdose Danocrine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Lab tests, including liver function tests and complete blood cell counts, may be performed while you use danazol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Abnormalities in laboratory tests may occur during therapy with Danazol including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins. furosemide
Xiol X, Martinez-Lacasa J, Pons M, Marti E, Casais L "Jaundice after danazol therapy for endometriosis. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Metabolic side effects have included significant increases in low density lipoproteins LDL and decreases in high density lipoproteins HDL. Decreased glucose tolerance requiring adjustments in hyperglycemic control has occurred. Our Danocrine danazol Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. How should I take sirolimus Rapamune? Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. Use and dose must be determined by your doctor.
The physician therefore should be alert to this possibility. In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What other drugs will affect sirolimus Rapamune? Your doctor may occasionally change your dose to make sure you get the best results. Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. best price for lamivudine
What other drugs will affect danazol Danocrine? It should not be given intravenously. Sirolimus may also be used for purposes not listed in this medication guide. It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. Acne; changes in menstrual flow eg, spotting; changes in semen volume; decrease in breast size; excessively oily skin; flushing; hair loss; mild weight gain; sweating; vaginal itching or dryness; voice changes hoarseness, sore throat, change in pitch. Reversible oligospermia may occur in adult males after prolonged administration or excessive dosage. If this effect occurs, danazol can be discontinued and if restarted, a lower dosage should be utilized. Sirolimus is usually taken once a day. If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Benzyl alcohol can cross the placenta. See WARNINGS.
Do NOT take more medicine than prescribed unless advised to do so by your doctor. Danazol appears to be metabolized and the metabolites are eliminated by renal and fecal pathways. The two primary metabolites excreted in the urine are 2-hydroxymethyl Danazol and ethisterone. At least ten different products were identified in feces. Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, check with your doctor. cost of clozaril vs generic
Active thrombosis or thromboembolic disease and history of such events. Tegretol phenytoin Dilantin phenobarbital Luminal. Danocrine, persistent amenorrhea has occasionally been reported. What are the possible side effects of sirolimus Rapamune? Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received. If you think you have become pregnant while using the medicine, tell your doctor right away. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Sirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Danocrine can induce ALA synthetase activity and hence porphyrin metabolism. Abnormalities in laboratory tests may occur during therapy with Danocrine including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins. If any of these effects persist or worsen, tell your doctor or promptly. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Danocrine is doubled the increase in plasma levels is only about 35% to 40%. Laboratory monitoring of the hematologic state should be considered. This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
You should not use this medication if you are allergic to sirolimus. To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Stop using this medicine and check with your doctor if you have the following symptoms while taking this medicine: blurred vision; change in the ability to see colors, especially blue or yellow; headache; nausea; or vomiting. Does Danocrine oral have side effects? Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index. Hematologic side effects have included thromboembolic and thrombophlebotic events including sagittal sinus thrombosis some resulting in fatal strokes, and increased red cell production. Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism. FDA pregnancy category C. It is not known whether sirolimus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. Brunskill PJ "The effects of fetal exposure to danazol. This product's label may have been updated. The dosage is based on your medical condition and response to treatment. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The toxic effects of your carbamazepine may increase. Ask your health care provider any questions you may have about how to use danazol. Danazol is to be used only by the patient for whom it is prescribed. Do not share it with other people. hydroxychloroquine
Shaw RW, Farquhar JW "Female pseudohermaphroditism associated with danazol exposure in utero. Case report. Danazol can cause insulin resistance. Caution should be exercised when used with antidiabetic drugs. Danazol should not be administered to patients with: 1. Undiagnosed abnormal genital bleeding. 2. Markedly impaired hepatic, renal, or cardiac function. 3. Pregnancy. Administration of danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria. Take the sirolimus tablet with a full glass of water. Serious and sometimes fatal blood clots eg, stroke increased pressure in the head, and liver problems have been reported with the use of danazol. Notify your doctor immediately if you develop any of the following: calf or leg pain, redness, tenderness, or swelling; chest pain; fainting; headache; nausea or vomiting; shortness of breath; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; vision changes. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctor's instructions. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Schwartz R "Ambiguous genitalia in a term female infant due to exposure to danazol in utero. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine. The presence of other medical problems may affect the use of this medicine.
These conditions can be made worse by the fluid retention keeping too much body water that can be caused by this medicine. Danazol is a man-made form of a steroid. Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Disclaimer: Every effort has been made to ensure that the information provided by Multum, Truven Health Analytics, Inc. This information should not be used to decide whether or not to take danazol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about danazol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to danazol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using danazol. Therapy should continue uninterrupted for 3 to 6 months. Administration of danazol up to 9 months may be necessary. Should symptoms recur, danazol treatment may be reinitiated. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. The dosage requirements for continuous treatment of hereditary angioedema with Danazol capsules should be individualized on the basis of the clinical response of the patient. It is recommended that the patient be started on 200 mg, two or three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage by 50% or less at intervals of one to three months or longer if frequency of attacks prior to treatment dictates. If an attack occurs, the daily dosage may be increased by up to 200 mg. During the dose adjusting phase, close monitoring of the patient's response is indicated, particularly if the patient has a history of airway involvement. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. generic escitalopram buy shopping australia
The oral liquid solution comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. Do not use any other liquids to mix this medicine. Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. Duck SC, Katayama KP "Danazol may cause female pseudohermaphroditism. Further, food also delayed mean time to peak concentration of Danazol by about 30 minutes. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking danazol? This information is generalized and not intended as specific medical advice. In female patients, the use of danazol the active ingredient contained in Danocrine may result in virilization including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization. Inactive Ingredients: Corn Starch, Lactose, Magnesium Stearate, Talc. Using this medicine may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking this medicine, check with your doctor right away. The following reactions have been reported, a causal relationship to the administration of Danocrine has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. How should I take danazol Danocrine? What should I avoid while taking sirolimus Rapamune? Preliminary epidemiological evidence suggests that the use of danazol might increase the baseline risk of ovarian cancer in patients being treated for endometriosis.
Seifer DB, Freedman LN, Cavender JR, Baker RA "Insulin-dependent diabetes mellitus associated with danazol. Do not start, stop, or change the dosage of any medicine before checking with them first. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. If you are taking Rapamune oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away. chib.info amoxil
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If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Jick SS, Myers MW "A study of danazol's safety. Andriole GL, Brickman C, Lack EE, Sesterhenn IA, Javadpour N, Linehan WM, Frank MM "Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema.
At first, 200 to 400 milligrams mg divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danazol to receptors of gonadal steroids at target organs. In addition, Danazol has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease.
Yaginuma T, Okamura T, Takeuchi T, Nishii O, Fujimori R "Preventive effect of traditional herbal medicine, shosaiko-to, on danazol-induced hepatic damage. Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. Bretza JA, Novey HS, Vaziri ND, Warner AS "Hypertension: a complication of danazol therapy. Do not receive a "live" vaccine while using sirolimus. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella MMR oral polio, typhoid, chickenpox varicella BCG Bacillus Calmette and Guérin and nasal flu vaccine.
Following an initial favorable response prevention of edematous episodes attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg. What other drugs will affect danazol? The risk of myopathy and rhabdomyolysis is increased by concomitant administration of Danazol with statins such as simvastatin, atorvastatin and lovastatin. Caution should be exercised if used concomitantly. Consult the product labeling for statin drugs for specific information on dose restrictions in presence of Danazol.